I posted a while back when I joined and have a new question: has anyone seen immunoglobulins go way up and down prior to diagnosis?

Brief history is my son - not diagnosed- was referred to immuno with low IgG and borderline IgA. (Found that while investigating recurrent pneumonia - 3x in 6 months, along with a few ear infections and strep throats).

Subsequently he had a normal IgG on repeat labs (that was early or mid November I think), and they said the first low test may have been lab error. Been in limbo since then. Since that test though, he's had a string of infections and a possible return to the immunologist has been mentioned.

He finished antibiotics *yesterday* for the second strep since early Dec and today has an acute ear infection. We had to go to urgent care since its the weekend and haven't been able to speak to the pediatrician. He is almost 6 and is also underweight and has GI issues. Lately he can't seem to go more than a couple of weeks without antibiotics; this time he hasn't even made it 36 hours. If I hadn't seen it myself I'd hardly believe the ear infection.

I know we need to continue with all the follow up vaccine titers .....we didn't complete all the follow up tests once the IG levels came back inside range.

But I can't help but wonder about the IGs- can they go up and down? by a lot? they were never absent, but were significantly below range, then jumped 300 points to well inside normal range on the repeat test. Maybe it really WAS a fluke, but I also wondered if maybe they are actually not consistently strong and that is part of the picture..or maybe we are at an early stage of dysfunction where they are fluctuating, or something. Has anyone seen anything like this? are we just totally on the wrong track?

I know I should just be patient with the process..but I'm really having trouble keeping any kind of perspective here. Ugh.

thanks.

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